ABSTRACT
Introduction: ghrelin is a 28-amino Aside peptide that predominantly produced by the stomach, which is the major source of systemic ghrelin. The anorexigenic and orcxigcnic hormones leptin and Ghrelin acted in opposite of each other. There are limited sn1dies related to levels of leptin in hematopoiesis, and there is no literature pertaining to the effects of ghrelin on hematopoiesis
Objective: determination the effect of Ghrelin on Hematopoietic Wistar Rats
Materials and Methods: 30 ma le Wistar rats were allocated for this study and were randomly divided into control and experimental groups. To monitor the effects of Ghrelin on blood parameters including hematocrit, albumin, total protein and white blood cells differential count, a general protocol of SC injection of Ghrelin [1 nmol/100microl N/saline] or 100 microl vehicle [physiological saline] to the control group was applied once a day for 10 consecutive days. The animals were killed by decapitation on days 5 and 15 after the last injection and above mentioned parameters were measured after their blood collection
Results: hematocrit percentage and RBC count significantly increased on day 5 and MCV decreased on this day [p< 0.05] However there was no significant difference in other parameters
Conclusion: it seems that Ghrelin ac1s directly via bone marrow or indirectly increases ACTH or growth hormone secretion and 1here fore modulates hematopoiesis